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Bronchiolitis Obliterans






  • This is a type of respiratory infection in which there is an inflammation of the lungs at the level of the bronchioles (part of the "bronchial tree").

  • Cough usually dry
  • There may be fever
  • Shortness of breath
  • Weight loss

  • Toxic fume bronchiolitis obliterans
  • Postinfectious bronchiolitis obliterans
  • Bronchiolitis obliterans associated with connective tissue diseases or organ transplant
  • Bronchiolitis obliterans associated with lung lesions (such as tumors)
  • Idiopathic (unknown cause) bronchiolitis obliterans

  • Lung crackles on exam
  • Pulmonary function tests show obstruction
  • Chest X-Ray may show "ground glass" appearance

  • Bronchiolitis obliterans usually requires no treatment except remove offending agent, if known.
  • Steroids (e.g., prednisone) may be prescribed to reduce inflammation.
  • BOOP (Bronchiolitis Obliterans with Organizing Pneumonia) -- treated with corticosteroids

  • It may be associated with an organizing Pneumonia (this condition is known as BOOP).
  • Symptoms include dry cough, shortness of breath, body and muscle aches, fever, and weight loss.
  • Chest X-Ray may show a patchy, ground glass, or diffuse alveolar infiltrates.

  • Respiratory bronchiolitis -- occurs in young smokers, presenting cough, shortness of breath, and lung crackles
  • Diffuse panbronchiolitis -- shortness of breath, cough with phlegm, and lung crackles.  This occurs almost exclusively in Japan, with 2/3 of those affected being male (age range 20 to 80 years old).
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