- Tachycardia (heart rate is elevated usually above 100)
- Heart exam may reveal a pericardial rub
- Tachypnea (rapid breathing)
- Pulsus paradoxus (systolic blood pressure drops by more than 10 mm Hg during inspiration)
- Ascites (swelling of the abdomen) and edema (leg swelling) may be present
- Central venous pressure (may be checked with a special catheter) is usually elevated
- Laboratory tests, e.g., sedimentation rate, ANA, rheumatoid factor.
- Chemistry panel to check kidney function and assess for uremic pericarditis (as well as other abnormalities). Complete blood count and thyroid function tests should be evaluated.
- Consider TB skin testing
- Chest X-Ray shows an enlarged cardiac silhouette
- EKG usually shows low voltage. Electrical alternan, if present, confirms the diagnosis (but is often not). Also check for signs of pericarditis-diffuse ST elevation or diffuse T wave inversions (be cautious, as may mimic a heart attack or a juvenile pattern)
- Echocardiogram confirms the diagnosis
- Pericardiocentesis (removal of fluid from the pericardial sac) can be used to treat the Pericardial Effusion/tamponade and the fluid can be sent to the lab and help make the diagnosis.
- Pericardial biopsy may be necessary to determine the cause of the Pericardial Effusion
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